The c.2524_2535delinsTCAGA (p.Ala842Serfs*7) variant in PALB2 is a frameshift variant predicted to cause a premature stop codon in biologically-relevant-exon 6 leading to nonsense mediated decay in a gene in which loss-of-function is an established disease mechanism. This variant is absent from gnomAD v2.1.1. This alteration results in a termination codon upstream of the most C-terminus pathogenic alteration (PALB2 p.Tyr1183*) as classified by the HBOP VCEP, and is expected to be more deleterious. In summary, this variant meets criteria to be classified as pathogenic for autosomal dominant hereditary breast and pancreatic cancer and autosomal recessive FANCN based on the ACMG/AMP criteria applied as specified by the HBOP VCEP. (PVS1, PM2_Supporting, PM5_Supporting)