Identifier Base Mean log2 Fold Change Standard Error p-value Adjusted p-value
hsa-miR-216a-5p 11.73 -0.3261 0.2335 0.1624 0.5104
hsa-miR-195-5p 337 -0.6399 0.2272 0.004855 0.08092
hsa-miR-516b-5p 18.64 0.5154 0.2202 0.01922 0.1471
hsa-miR-15b-3p 2.137 -0.5811 0.2748 0.03446 0.223
hsa-miR-744-5p 134.1 0.2246 0.168 0.1814 0.534
hsa-miR-543 1.067 0.4154 0.3056 0.174 0.5229
hsa-miR-222-3p 133.7 0.2083 0.1324 0.1156 0.4329
hsa-miR-518c-3p 4.567 0.4571 0.288 0.1126 0.4269
hsa-miR-708-5p 8.23 -0.506 0.2798 0.07054 0.3233
hsa-miR-374c-5p 2.386 -0.7428 0.3142 0.01807 0.1471
hsa-miR-320a 2774 -0.2633 0.2122 0.2146 0.5932
hsa-miR-98-5p 890.4 -0.3131 0.2238 0.1618 0.5104
hsa-miR-22-5p 9.742 -0.299 0.1996 0.1341 0.4763
hsa-miR-20b-5p 3.407 -0.4525 0.273 0.09742 0.3999
hsa-miR-19a-3p 58.98 -1.101 0.2529 1.342e-05 0.002459
hsa-miR-184 15.73 -0.4811 0.2417 0.04653 0.2592
hsa-miR-24-3p 288.7 -0.3185 0.1713 0.063 0.3056
hsa-miR-191-5p 7952 0.4149 0.1649 0.01188 0.1281
hsa-miR-3909 3.402 0.5185 0.1916 0.006806 0.09981
hsa-miR-769-3p 2.305 -0.7445 0.285 0.008996 0.1099
hsa-miR-518b 3.4 0.5034 0.3231 0.1192 0.44
hsa-miR-100-3p 1.292 -0.5 0.3083 0.1048 0.409
hsa-miR-424-5p 15.72 -0.5285 0.264 0.04527 0.2592
hsa-miR-29a-3p 713.4 -0.2747 0.1444 0.05708 0.2881
hsa-miR-483-3p 5.546 0.373 0.2539 0.1418 0.4936
hsa-let-7i-3p 14.68 -0.3535 0.2093 0.09128 0.3892
hsa-miR-212-3p 2.296 -0.4818 0.2776 0.08262 0.357
hsa-miR-873-5p 31.13 -0.8696 0.257 0.0007153 0.02459
hsa-miR-499a-5p 2.54 -0.4699 0.2202 0.03284 0.215
hsa-miR-339-3p 31.27 0.1667 0.1281 0.1931 0.559
hsa-miR-517a-3p|hsa-miR-517b-3p 3.849 0.4306 0.27 0.1108 0.4232
hsa-miR-218-5p 54.44 -0.7227 0.1953 0.0002154 0.01077
hsa-miR-101-5p 5.287 -0.5073 0.2167 0.01926 0.1471
hsa-miR-33a-5p 3.044 -0.9939 0.2953 0.0007641 0.02472
hsa-miR-590-3p 1.548 -0.7198 0.3031 0.01754 0.1471
hsa-miR-1294 1.485 0.7863 0.3054 0.01003 0.1103
hsa-miR-374a-5p 7.641 -0.6751 0.2839 0.01742 0.1471
hsa-miR-26a-2-3p 8.387 -0.5299 0.2392 0.02673 0.1847
hsa-miR-30e-3p 843.4 -0.5158 0.168 0.002141 0.05069
hsa-miR-1247-5p 2.826 0.4461 0.2739 0.1034 0.409
hsa-miR-4665-5p 0.8935 0.9887 0.34 0.003636 0.07406
hsa-miR-129-5p 197.1 -0.4883 0.2382 0.04033 0.2385
hsa-miR-421 88.31 -0.2611 0.1568 0.09589 0.3965
hsa-miR-652-3p 133.6 -0.3023 0.1465 0.03908 0.2376
hsa-miR-140-5p 11.96 -0.4441 0.221 0.04451 0.2577
hsa-miR-145-5p 32.25 -0.4422 0.2289 0.0534 0.279
hsa-miR-454-3p 9.407 -0.3519 0.2651 0.1843 0.5392
hsa-miR-518a-3p 3.806 0.467 0.311 0.1332 0.4763
hsa-miR-30d-5p 7823 0.3061 0.1766 0.08309 0.357
hsa-miR-103a-2-5p 1.271 -0.4903 0.278 0.07782 0.3452
hsa-miR-20a-5p 9.695 -0.5281 0.2867 0.06546 0.3097
hsa-miR-192-5p 911.8 -0.5429 0.1768 0.002133 0.05069
hsa-miR-129-2-3p 21.59 -0.5972 0.2487 0.01636 0.1466
hsa-let-7g-3p 6.794 -1.045 0.2701 0.0001099 0.007553
hsa-miR-208b-3p 14.91 -0.263 0.1932 0.1734 0.5229
hsa-mir-378c 14.04 -0.3585 0.251 0.1532 0.5104
hsa-miR-378d 6.854 0.3224 0.2269 0.1553 0.5104
hsa-miR-29b-3p 42.76 -0.2563 0.1812 0.1572 0.5104
hsa-miR-92a-3p 2326 0.5404 0.2234 0.01556 0.1442
hsa-miR-495-3p 5.71 -0.6788 0.2979 0.0227 0.1621
hsa-miR-1270 1.468 -0.6518 0.3004 0.03002 0.2039
hsa-miR-150-5p 13.18 0.7764 0.3014 0.009993 0.1103
hsa-miR-664b-5p 0.9518 -1.321 0.3088 1.906e-05 0.00262
hsa-miR-381-3p 40.51 -0.3831 0.2581 0.1376 0.4853
hsa-miR-3065-3p 3.8 -0.3651 0.2438 0.1342 0.4763
hsa-miR-887-3p 49.91 -0.3398 0.186 0.06776 0.3158
hsa-miR-181a-2-3p 84.49 -0.4906 0.1523 0.001273 0.0389
hsa-miR-32-5p 15.88 -0.8086 0.2379 0.0006755 0.02459
hsa-miR-219a-1-3p 1.188 -0.4361 0.3396 0.1992 0.5676
hsa-miR-34a-5p 119.7 -0.1875 0.1404 0.1816 0.534
hsa-miR-1908-5p 1.382 0.391 0.2823 0.166 0.5112
hsa-miR-132-3p 34.48 -0.3128 0.1751 0.07403 0.3356
hsa-miR-455-5p 4.589 -0.6852 0.259 0.008153 0.1043
hsa-miR-2114-3p 0.9122 -0.7652 0.3139 0.01477 0.1426
hsa-miR-210-3p 139.3 -0.4431 0.215 0.03931 0.2376
hsa-miR-190a-3p 3.413 -1.208 0.3007 5.916e-05 0.005423
hsa-miR-320b 220.3 -0.2905 0.2291 0.2047 0.5775
hsa-miR-181d-5p 105.6 -0.2441 0.1785 0.1715 0.5213
hsa-miR-34c-3p 423.1 0.3009 0.2174 0.1664 0.5112
hsa-miR-1224-5p 1.819 -0.4736 0.3297 0.1509 0.5104
hsa-miR-874-3p 83.78 -0.3187 0.1786 0.07444 0.3356
hsa-miR-512-3p 16.8 0.6189 0.2626 0.01842 0.1471
hsa-miR-9-3p 47.91 -0.5152 0.2169 0.01752 0.1471
hsa-miR-491-5p 6.372 -0.5443 0.2834 0.05479 0.2816
hsa-miR-21-5p 1916 -0.2004 0.1555 0.1973 0.5653
hsa-miR-345-5p 111.4 0.2502 0.1606 0.1191 0.44
hsa-miR-1287-5p 6.749 -0.3614 0.1964 0.06572 0.3097
hsa-miR-377-3p 1.138 -0.6525 0.328 0.04666 0.2592
hsa-miR-561-5p 20.28 -0.4337 0.1848 0.0189 0.1471
hsa-miR-181b-5p 1243 -0.6452 0.2335 0.005722 0.09236
hsa-miR-182-5p 255.6 0.7238 0.2805 0.00988 0.1103
hsa-miR-122-5p 44.95 -1.152 0.2344 8.822e-07 0.0003354
hsa-miR-708-3p 14.95 -0.3396 0.2401 0.1572 0.5104
hsa-miR-375 472.5 0.5496 0.1796 0.002212 0.05069
hsa-miR-628-5p 2.817 -0.6014 0.2509 0.01652 0.1466
hsa-miR-152-3p 179.2 -0.346 0.1604 0.03095 0.2076
hsa-miR-519d-5p 2.042 -0.5279 0.3795 0.1642 0.5104
hsa-miR-671-3p 9.541 0.3075 0.2085 0.1403 0.4916
hsa-miR-4685-3p 1.311 0.5246 0.3185 0.09951 0.4054
hsa-miR-335-5p 231.9 -0.3788 0.1821 0.03751 0.2346
hsa-miR-95-3p 8.026 -0.5631 0.2089 0.007018 0.09981
hsa-miR-301a-3p 33.63 -0.5169 0.214 0.01573 0.1442
hsa-miR-582-5p 2.057 -1.176 0.3107 0.0001544 0.009436
hsa-miR-93-3p 4.644 0.2963 0.2314 0.2003 0.5679
hsa-miR-215-5p 5.493 0.3709 0.2634 0.1591 0.5104
hsa-miR-191-3p 5.012 0.3667 0.2283 0.1082 0.4188
hsa-miR-99a-3p 30.71 -0.3282 0.1619 0.04261 0.2493
hsa-miR-1323 13.08 0.4553 0.284 0.1089 0.4188
hsa-miR-425-5p 68.87 0.437 0.1867 0.01926 0.1471
hsa-miR-451a 1019 -0.6724 0.2916 0.02112 0.1549
hsa-miR-193a-3p 4.814 -0.9287 0.3256 0.004341 0.07934
hsa-miR-19b-3p 473.1 -1.055 0.2174 1.219e-06 0.0003354
hsa-miR-520d-5p 0.9663 0.7872 0.3454 0.02266 0.1621
hsa-miR-376c-3p 9.639 -0.3824 0.2955 0.1956 0.5633
hsa-miR-873-3p 37.22 0.3597 0.2675 0.1787 0.5325
hsa-miR-1249-3p 2.697 -0.4921 0.3535 0.1638 0.5104
hsa-miR-106b-3p 148.2 -0.5346 0.1863 0.004098 0.07772
hsa-miR-4454 161.5 0.6829 0.2761 0.0134 0.139
hsa-miR-2467-5p 1.755 -0.5044 0.2585 0.05099 0.2702
hsa-miR-194-5p 7.595 -0.4072 0.1894 0.03151 0.2088
hsa-miR-374a-3p 17.24 -0.4547 0.2795 0.1037 0.409
hsa-miR-3158-3p 6.284 0.4523 0.2778 0.1036 0.409
hsa-miR-676-3p 3.959 -0.6538 0.2471 0.008155 0.1043
hsa-miR-101-3p 3781 -0.644 0.2101 0.002174 0.05069
hsa-miR-33a-3p 1.476 -0.5449 0.2922 0.06219 0.3054
hsa-miR-369-5p 3.923 0.5957 0.2905 0.04033 0.2385
hsa-miR-598-3p 26.36 -0.6448 0.2052 0.001677 0.04855
hsa-miR-378e 1.246 0.3997 0.3237 0.217 0.5967
hsa-miR-501-5p 7.386 0.338 0.241 0.1608 0.5104
hsa-miR-216a-3p 1.537 0.4996 0.2716 0.06588 0.3097
hsa-miR-190b 15.48 -0.4518 0.2176 0.03788 0.2346
hsa-miR-127-5p 14.17 -0.9497 0.268 0.0003949 0.01671
hsa-miR-26b-5p 848.2 -0.4001 0.2008 0.04632 0.2592
hsa-miR-211-5p 218.3 -0.518 0.188 0.005878 0.09236
hsa-miR-15b-5p 10.76 -0.5607 0.2282 0.01399 0.1399
hsa-miR-378b 4.644 0.5454 0.3005 0.06955 0.3214
hsa-miR-30a-3p 2423 -0.7086 0.1712 3.47e-05 0.003817
hsa-miR-4510 1.589 0.6807 0.3073 0.02673 0.1847
hsa-miR-374b-5p 47.09 -0.577 0.2005 0.003995 0.07772
hsa-miR-30d-3p 76.92 0.184 0.1289 0.1535 0.5104
hsa-miR-944 2.472 -0.9315 0.3021 0.002045 0.05069
hsa-miR-651-5p 3.19 -0.6772 0.2721 0.01283 0.1357
hsa-miR-542-3p 4.627 -0.7573 0.2874 0.008409 0.1051
hsa-miR-6716-3p 1.726 0.3862 0.2821 0.171 0.5213
hsa-miR-769-5p 901.1 -0.349 0.1999 0.08086 0.3548
hsa-miR-105-5p 30.25 0.4094 0.2096 0.05078 0.2702
hsa-miR-941 111.2 0.3315 0.1745 0.05744 0.2881
hsa-miR-106a-5p 4.41 -0.7083 0.2744 0.009855 0.1103
hsa-miR-520a-3p 5.752 0.5893 0.3127 0.05945 0.2946
hsa-miR-28-3p 1455 0.3539 0.1374 0.009992 0.1103
hsa-miR-532-5p 295.8 -0.1944 0.1563 0.2135 0.5932
hsa-miR-30b-3p 1.084 0.4341 0.3053 0.1551 0.5104
hsa-miR-181a-3p 50.14 -0.3094 0.2001 0.122 0.4474
hsa-miR-500a-3p 132.5 0.2008 0.1277 0.1157 0.4329
hsa-miR-103a-3p 637.1 -0.2766 0.1587 0.08128 0.3548
hsa-miR-942-5p 1.124 1.36 0.3512 0.0001077 0.007553
hsa-miR-148b-3p 735.2 -0.4501 0.1917 0.01888 0.1471
hsa-miR-574-5p 1.661 -0.5533 0.2802 0.04829 0.2631
hsa-miR-4787-3p 3.18 -0.5236 0.226 0.02049 0.1544
hsa-miR-320c 22.74 -0.6488 0.2439 0.007807 0.1043
hsa-miR-767-5p 291.9 0.3128 0.22 0.155 0.5104
hsa-miR-483-5p 85.01 0.3662 0.2573 0.1545 0.5104
hsa-miR-29c-3p 377.4 -0.3163 0.1666 0.05762 0.2881
hsa-miR-548k 1.304 -0.4166 0.3157 0.1869 0.5439
hsa-miR-376a-3p 3.151 -0.6149 0.2955 0.03743 0.2346
hsa-miR-660-5p 225.9 -0.4455 0.1492 0.002828 0.05983
hsa-miR-199b-5p 4.129 -0.778 0.2753 0.00472 0.08092
hsa-miR-34a-3p 4.589 -0.5446 0.2236 0.01486 0.1426
hsa-miR-5683 1.767 -0.6294 0.339 0.06335 0.3056
hsa-miR-223-5p 1.748 0.4246 0.3408 0.2129 0.5932
hsa-miR-484 47.03 0.3633 0.2212 0.1005 0.4064
hsa-miR-382-3p 3.074 -0.6494 0.3129 0.03796 0.2346
hsa-miR-1296-5p 18.35 -0.3505 0.2161 0.1048 0.409
hsa-miR-2276-3p 1.38 0.5847 0.2961 0.04832 0.2631
hsa-miR-3200-3p 12.83 -0.5051 0.1905 0.008024 0.1043
hsa-miR-380-3p 1.004 0.4968 0.3946 0.2081 0.5839
hsa-miR-1911-3p 71.58 0.292 0.2173 0.1791 0.5325
hsa-miR-124-5p 1.737 -0.4723 0.3371 0.1613 0.5104
hsa-miR-125a-5p 2991 0.3801 0.2483 0.1258 0.4581
hsa-miR-628-3p 4.094 0.3552 0.2124 0.0945 0.3938
hsa-miR-219a-5p 96.61 -0.8066 0.2995 0.007077 0.09981
hsa-miR-219a-2-3p 363.2 -0.7007 0.2882 0.01504 0.1426
hsa-miR-665 1.02 -1.29 0.3733 0.000551 0.02164
hsa-miR-548ba 1.911 -0.6362 0.3261 0.05109 0.2702
hsa-miR-539-3p 1.868 -0.4981 0.2971 0.09358 0.3929
hsa-miR-548ab 0.8959 -0.8038 0.326 0.01368 0.1393
hsa-miR-340-5p 340.5 -0.8657 0.2305 0.0001724 0.009479
hsa-miR-3065-5p 4.156 -0.3258 0.2316 0.1595 0.5104
hsa-miR-135a-5p 139.5 -0.3593 0.2363 0.1284 0.4644
hsa-miR-452-5p 6.608 -0.7033 0.2474 0.004472 0.07934
hsa-miR-181a-5p 12460 -0.3615 0.1874 0.05376 0.279
hsa-miR-29c-5p 43.06 -0.2819 0.1975 0.1536 0.5104
hsa-miR-641 4.384 0.4576 0.2577 0.0758 0.3389
hsa-miR-2114-5p 1.677 -1.221 0.3327 0.0002428 0.01113
hsa-miR-378c 4.277 0.6298 0.273 0.02105 0.1549
hsa-let-7b-5p 2839 -0.2023 0.1419 0.1539 0.5104
hsa-miR-518e-3p 4.926 0.4886 0.2903 0.09233 0.3906
hsa-miR-9-5p 1033 -0.7469 0.2479 0.002582 0.0568
hsa-miR-199a-3p|hsa-miR-199b-3p 405.3 -0.5396 0.2438 0.02686 0.1847
hsa-miR-550a-3-5p|hsa-miR-550a-5p 2.2 0.8058 0.2939 0.006113 0.0934

Understanding Your Results

The table above displays differentially expressed miRNAs for selected Atlas data.
  • The Checkbox column allows you to select a given miRNA for further downstream analysis.
    You can click the checkbox in the upper left corner of the table to select all visible miRNAs.
  • The Identifiers column contains all of your miRNA identifiers.
  • The Base Mean column contains "the average of the normalized count values, divided by the size factors, taken over all samples [in the original dataset]" for each miRNA.[1]
  • The log2 Fold Change column contains the "effect size estimate" for each miRNA.[1]
  • The Standard Error column contains the "standard error estimate for the log2 fold change estimate" for each miRNA.[1]
  • The p-value column contains the Wald test p-value for each miRNA.[1]
  • The Adjusted p-value column contains the Benjamini-Hochberg adjusted p-value for each miRNA.[1]
By default, the table is sorted by adjusted p-value, but you can sort by any of the columns.

Downstream Analysis

When you have selected your miRNAs of interest (via the checkboxes on the left side of the table),
you can perform downstream analyses by clicking the "Analyze Selected miRNAs" button above the table.

See descriptions of all available downstream analysis tools below.

Pathway Finder
  • Use Pathway Finder (hosted by WikiPathways) to find pathways containing miRNAs of interest (or protein targets of those miRNAs).
  • Click a given pathway title to visualize its contents at the bottom of the page.
  • Then, select a given miRNA to highlight its associated target(s).
  • The pathway visualization is interactive - zoom in or out by using the + and - icons, and click a given gene product to learn more about it.
  • Designed and implemented by Kristina Hanspers, Anders Riutta, and Alexander Pico at the Gladstone Institutes, San Francisco, CA.
  • Integrated into the exRNA Atlas by William Thistlethwaite and Neethu Shah at the Bioinformatics Research Lab, Baylor College of Medicine, Houston, TX.

References

[1] Love, M. I., Anders, S., Kim V., & Huber W. (2017, Aug 9). RNA-seq workflow: gene-level exploratory analysis and differential expression. Retrieved from http://www.bioconductor.org/help/workflows/rnaseqGene/
DESeq2 designed and implemented by Michael Love, Simon Anders, and Wolfgang Huber (PubMed).
DESeq2 integrated into the exRNA Atlas by William Thistlethwaite and Neethu Shah at the Bioinformatics Research Lab, Baylor College of Medicine, Houston, TX.