The exRNA Atlas is the data repository of the Extracellular RNA Communication Consortium (ERCC). The repository includes small RNA sequencing and qPCR-derived exRNA profiles from human and mouse biofluids. All RNA-seq datasets are processed using the exceRpt small RNA-seq pipeline (Rozowsky et al., 2019) and ERCC-developed quality metrics are uniformly applied to these datasets.

If you're interested in viewing the version of the Atlas used in the Cell paper "ExRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present Across Human Biofluids" (Murillo et al., 2019), please see the associated Atlas Snapshot.

If you're interested in submitting your RNA-seq or qPCR data to the Atlas, view our Submission Guide.

We are in the process of modifying the way exRNA Atlas data files are stored. As part of this update, exRNA Atlas samples have been reprocessed using the hg38 reference genome and the exceRpt v5.0 small RNA-seq pipeline. This newly processed data (Atlas v3.0), is being integrated into the main exRNA Atlas webpage search and download functions. During the upgrade, Atlas v3.0 data can be downloaded through a publicly available FTP. The five most prevalent biofluids in the Atlas (Plasma, Serum, Saliva, Urine, Cerebrospinal Fluid) comprise about 97% of all Atlas samples. Data for these five biofluids is available in Atlas v3.0 (that meet study size and QC benchmarks). The remaining biofluids will be integrated in the near future. At this time, legacy sample download is unavailable for hg19 data but will be available alongside the new hg38 data in the near future.

This repository is under review for potential modification in compliance with new administrative regulations, data security standards. We are also lifting over the exRNA profiles to the hg38 reference genome.